ABSTRACT
In 30 patients subjected to craniotomy for cerebral aneurysm, the correlation of cerebral blood flow and cerebral metabolism were evaluated by measuring mean arterial pressure (MAP) and cerebral arterio-venous oxygen content differences(AVDO2) during isoflurane and neurolept anesthesia. 15 patients were given 1 MAC isoflurane anesthesia and 15 patients neurolept anesthesia. MAP, AVDO2 and PaCO2 were measured before skin incision, after skin incision, after opening of dura and after closing of dura. The results were as follows: 1) In both groups, significant increases in MAP was observed after skin incision(P<0.05), no significant difference between the two groups was found. 2) In both groups, significant decreases in AVDO2 was observed after skin incision (<0.05), AVDO, values showed insignificant difference. The results indicate that even moderate increases in MAP after skin incision during isoflurane and neurolept anesthesia affect AVDO2 values, suggesting increases in cerebral blood flow. Therefore measures that prevent increase in MAP during incision should be implemented. The study suggests that isoflurane anesthesia is as useful as neurolept anesthesia in terms of AVDO2 to patients undergoing aneurysmal surgery.